Pro Bio S and -NP Pro are dedicated especially for Aquaforest Probiotic Method. We’re aware that not everyone uses full Probiotic Method, so, listening to our customers, we decided to create product that will be suitable for all kinds of tanks. NitraPhos Minus was designed to quickly remove from the high levels of nitrate and phosphate. You can use both products together, but nitrate and phosphate levels reduction will be very strong and you should carefully observe your aquarium.